Altered cartilage phenotype in mice lacking Sirt 1 gene

Altered respiratory pattern and hypoxic response in transgenic newborn mice lacking the tachykinin-1 gene.

Substance P is known to be involved in respiratory rhythm and central pattern-generating mechanisms, especially during early development. We therefore studied respiratory responses in transgenic newborn mice (Tac1(-/-)) lacking substance P and neurokinin A (NKA). In vivo, the effects of intermittent isocapnic hypoxia (IH) and hypercapnia were studied using whole body flow plethysmography at P2-...

Thymoquinone ameliorates diabetic phenotype in Diet-Induced Obesity mice via activation of SIRT-1-dependent pathways

Thymoquinone, a natural occurring quinone and the main bioactive component of plant Nigella sativa, undergoes intracellular redox cycling and re-oxidizes NADH to NAD+. TQ administration (20 mg/kg/bw/day) to the Diet-Induced Obesity (DIO) mice reduced their diabetic phenotype by decreasing fasting blood glucose and fasting insulin levels, and improved glucose tolerance and insulin sensitivity as...

Articular Cartilage and Intervertebral Disc Degeneration in Mice Lacking Early Growth Response Protein-1 (EGR-1)

Articular Cartilage and Intervertebral Disc Degeneration in Mice Lacking Early Growth Response Protein-1 (EGR-1) Kevin Debiparshad1, Fackson Mwale1, Peter Roughley2, Lorraine Chalifour3, John Antoniou1 1Division of Orthopaedic Surgery, McGill University, Montreal, QC, Canada; 2Department of Surgery, McGill University, Montreal, QC, Canada; 3Division of Experimental Medicine, McGill University, ...

Mice lacking bi-1 gene demonstrate accelerated liver regeneration

Mice lacking bi-1 gene show accelerated liver regeneration.

The liver has enormous regenerative capacity such that, after partial hepatectomy, hepatocytes rapidly replicate to restore liver mass, thus providing a context for studying in vivo mechanisms of cell growth regulation. Bax inhibitor-1 (BI-1) is an evolutionarily conserved endoplasmic reticulum (ER) protein that suppresses cell death. Interestingly, the BI-1 protein has been shown to regulate C...